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CBG or Cannabigerol

You’re probably well aware of CBD and its vast potential in the health and wellness scene by now. Aside from cannabidiol, hemp also has other cannabinoids. There are also THC, CBN, CBDa, THCa, and others, but here we will focus on CBG.

CBG, or cannabigerol, is also a cannabinoid with vast untapped potential. Its importance in the grand scheme of the cannabinoid landscape has earned it the name, “the mother of all cannabinoids.”

What Are The Benefits Of CBG?

Researchers are starting to notice the many possible benefits of CBG. There is optimism surrounding CBG for the treatment of a wide variety of medical conditions.

McMaster University researchers found that CBG has antifungal and antimicrobial properties so potent that it can fight off bacterial strains like MRSA, which are notoriously resistant to antibiotics. CBG is shown to be a superior bacteria fighter to THC, CBD, or CBC.

CBG shows potential in the treatment of inflammatory conditions such as inflammatory bowel disease (IBD). A study published in the journal, Biochemical Pharmacology, found that CBG reduced inflammation in mice with colitis.

Anxiety and depression:
CBG inhibits the uptake of serotonin and GABA, which helps regulate our moods. This suggests that CBG may have antidepressant qualities. The mental healt benefits of CBG are still being explored, but show great promise.

Bladder dysfunction:
Based on a study published in the Indian Journal of Urology, cannabidiol has been proven to be more effective than other cannabinoids at inhibiting muscle contractions in the human bladder, which may help treat symptoms associated with many bladder disorders.

Cannabics Pharmaceuticals sponsored a study showing CBG killing gastrointestinal cancer cells. CBG inhibited cancer cell growth, displayed antitumor properties, and slowed disease development. The study, led by a group of Israeli researchers, found CBG to inhibit the growth of prostate cancer cells. CBG may also stimulate appetite, which could help counteract one of the adverse effects of chemotherapy.

Muscle relaxant:
According to a study by Ethan B Russo from GW Pharmaceuticals, CBG may act as a natural muscle relaxant. CBG may prove useful in the management of chronic pain and/or sports injuries.

CBG shows the potential to combat cognitive decline. A 2015 study published in the journal Neurotherapeutics suggests that CBG may help people with Huntington’s disease. Because of its potential for the treatment of Huntington’s disease, CBG may also be able to help with other neurological conditions like Parkinson’s or Alzheimer’s disease.

Pain Relief: 
CBG may have pain-relieving properties, according to a study from the British Journal of Pharmacology. It was found to be more effective than even THC at treating pain.

Evidence also supports the notion that the interaction of CBG with the body’s endocannabinoid system could also make it a viable treatment option for psoriasis. Human trials are underway in a study funded by AXIM Biotech and conducted by world-renowned dermatologist and specialist on psoriasis and atopic dermatitis, these studies are conducted by Dr. Marcus Meinardi, at The Maurits Clinics in The Hague, The Netherlands.

Strengthen bones:
The results of a study conducted by researchers from the Federation of European Neuroscience Societies and John Wiley & Sons Ltd indicate further benefits of CBG. CBG could potentially grow bone marrow to help strengthen bones and heal fractures, possibly even to protect against the development of osteoporosis.

benefits of CBG - "the mother of all cannabanoids"

What Is CBG?

CBG, like CBD, is a non-psychoactive cannabinoid found most abundantly in low-THC, high-CBD hemp strains. CBG interacts with the cannabinoid receptors in the brain, and counteracts the psychoactivity of THC.

CBG is found in smaller concentrations in the hemp plant than the more notable cannabinoids. This is because the amount of CBG in the plant declines as the plant ages.

The primary role of CBG is to synthesize other types of cannabinoids, which prompted it to be called the “mother of all cannabinoids”. Let’s examine this further.

Why is CBG considered to be the mother of all cannabinoids?
CBG is called the mother of all cannabinoids because all other cannabinoids originate from CBG. The acidic precursor of CBG, CBGa, functions as a precursor for THC, CBD, and other cannabinoids.

It is the base compound CBGa, or cannabigerolic acid, that provides the source material for all other cannabinoids. Under certain circumstances, it also morphs into other acids (THCa, CBDa, CBCa, etc.).

Once they transform, these precursors will eventually become their full, respective cannabinoids. CBGa, in this regard, is the mother of all cannabinoids, while CBG is named the “Princess of Pot” because as the offspring of CBGa.


CBD and CBG share one obvious similarity—they both derive from CBGa. They may have the same benefits in the future as new research is conducted, but they aren’t exactly the same.

One difference between CBD and CBG is that CBG directly binds to the brain’s CB1 and CB2 receptors while CBD produces its benefits in a more indirect manner through our endocannabinoid system.

CBG Side Effects

We have discussed the benefits of CBG. Now let’s discuss the side effects of CBG.

To date, little is known about any possible side effects of CBG. Studies show it is well-tolerated by rats, but human trials would be needed to make real and conclusive claims, especially when it comes to understanding how CBG interacts with other medications.

When taken in proper doses, CBG has not been shown to have any side effects (read the label of your product and adhere to the manufacturer recommendations). Regardless, we can say that users may experience negative side effects when they consume too much CBG.

These effects may include fatigue, diarrhea, dry mouth, and changes to your appetite. Because one would have to take a massive amount of CBG to experience negative side effects, so it seems unlikely that a person will experience side effects.

Will CBG Get Me High?
No, Since CBG is non-psychoactive, it won’t get you high. On the contrary, CBG counters some of the paranoia-causing effects of THC. In the absence of CBG, users may have bad experiences and negative effects from marijuana strains that have a high THC concentration.

Is CBG Safe For Me?
Absolutely. Since there are no known side effects at this point—and since CBG won’t make you high—CBG is safe until proven otherwise (and again, only if it is used at appropriate doses).

CBG shows great potential to help with a variety of conditions ranging from cancer to osteoporosis. CBG may never reach the popularity of some of its cannabinoid counterparts (i.e., CBD and THC) because it is much less abundant and therefore much more difficult to extract, however some circumstances make it the better option.

CBG appears to be free of negative side effects, making it potentially an exciting and safe alternative to traditional medications like opioids.Further human studies are needed to prove CBG’s efficacy, but it is well on its way to becoming a more popular and attractive solution.

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